LifeSplice develops novel splice modulating oligomers (SMOs) that directly modulate dysregulated pre-mRNA splicing and alternative splicing which are both frequently linked to severe neurological disorders and a broad range of non-neurological diseases.
LifeSplice's SMOs therapeutic mechanism functions through the re-balancing and normalization of natural pre-mRNA splicing.
An example of alternative splicing of a gene and the modulation of alternative splicing by an SMO is demonstrated in the diagrams below.
